Analysis performed on 2024-09-30 10:19:54
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 46029 | 559 | 45470 | 26531 |
| Archaea | 3161 | 92 | 3069 | 1386 |
| Vertebrata | 1641 | 405 | 1236 | 473 |
| Mammals | 604 | 54 | 550 | 131 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 660 | 21 | 583 |
| Domains | |
|---|---|
| Current Study | 1, 73 |
| Guo et al (2010) | 5, 32 | 41, 64 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 588 | 72 | 660 | 8.166667 |
| Number of Variants | 528 | 76 | 604 | 6.947368 |
| Number of Pathogenic Variants | 16 | 5 | 21 | 3.200000 |
| Number of Benign/Unknown Variants | 512 | 71 | 583 | 7.211268 |
| Fisher exact test | 0.167580 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 608 | 52 | 660 | 11.692308 |
| Number of Variants | 553 | 51 | 604 | 10.843137 |
| Number of Pathogenic Variants | 19 | 2 | 21 | 9.500000 |
| Number of Benign/Unknown Variants | 534 | 49 | 583 | 10.897959 |
| Fisher exact test | 0.695035 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 588 | 72 | 0.89 (0.00) | 0.78 (0.02) | 9.293e-01 | 7.893e-01 | 28792.00 | 2.98e-07 |
| Guo et al (2010) | 608 | 52 | 0.88 (0.00) | 0.82 (0.02) | 9.271e-01 | 8.940e-01 | 18941.00 | 8.80e-03 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.